Calcium, Waves, Gradients and Oscillations
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Описание:
Calcium Waves, Gradients and Oscillations Chairman: Michael J. Berridge 1995 Standing free gradients are widespread in living systems and changes in intracellular free Ca 2+ concentration, [Ca 2+ ] i , are involved in controlling the responses of cells to many stimuli. Imaging techniques have revealed complex patterns of Ca 2+ distribution arising spontaneously or after stimulation of cells by hormones or neurotransmitters. In many cells, Ca 2+– mobilizing agonists stimulate oscillations in [Ca 2+ ] i , with the frequency of the concentration rises (‘spikes’) depending on the agonist concentration and the external Ca 2+ concentration. The Ca 2+ spikes are organized spatially as well as temporally, so that a regenerative wave spreadsacross the cell. Such Ca 2+ waves have been observed in many cell types: in hamster eggs, fertilization stimulates a Ca 2+ wave that spreads from the...Похожие книги
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