Critical Mediators of Multiple Sclerosis Disease Suppression
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Описание:
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS affecting nearly 3 million people world-wide. Patients present with a myriad of symptoms making MS difficult to diagnose. Clinical presentation of MS ranges from mild to severe, and no two patients can be said to demonstrate the same clinical course. Females are three times as likely as males to be affected, but males often present with a more severe disease course. Pregnancy suppresses MS severity in human and animal models. This is likely due to hormone and genetics regulation of proteins involved with inflammation such as PI3K proteins. PI3Ks are involved in cellular trafficking, growth and death. Sex dimorphism and pregnancy changes have been noted in both MS and experimental autoimmune encephalomyelitis, a commonly used animal model for MS. These models aid in research development and improve the understanding of immunological processes of the disease. The studies outlined in this book offer findings that...Похожие книги
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