Impact of M-current on neuronal excitability

Impact of M-current on neuronal excitability
Автор
 
Год
 
Страниц
 
132
ISBN
 
9783639149890
Категория
 
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Описание:

The M-current (of the KCNQ2/3 channel) is voltage- gated potassium current that controls neuronal excitability. Mutations of the KCNQ2/KCNQ3 genes cause BFNC, a neonatal form of epilepsy. Despite substantial research, we do not understand yet the mechanisms by which M-channels modulate neuronal excitability. This book, therefore, evaluates the impact of these channels on the excitability of hippocampal neurons and transmitter release. It appraises the impact of M-channels on spontaneous excitatory/inhibitory post-synaptic currents (sEPSCs/sIPSCs), as well as miniature EPSCs/IPSCs. It also assesses the possible contribution of somatic versus axonal/presynaptic M-channels to transmitter release, and explores a possible functional interaction between M-channels and SNARE proteins such as syntaxin-1A. This book should provide a basic understanding of the pathophysiological processes of neuronal hyperexcitability and also afford a therapeutic potential for the treatment of major...

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