Mechanosensitivity in Cells and Tissues

Mechanosensitivity in Cells and Tissues
Автор
 
Год
 
Страниц
 
480
ISBN
 
5769525908
Издатель
 
Академия
Категория
 
Разное

Содержание:

Философия

Описание:

International scientists have come together to create a book on mechanosensitivity in cells and tissues. Mechanosensitivity, i.e. the specific response to mechanical stimulation, is common to a wide variety of cells in many different organisms ranging from bacteria to mammals. Mechanical stress can modulate physiological processes at the molecular, cellular, and systemic level. The primary target for mechanical stimulation is the plasma membrane of the cell, which can respond to variable physical stress with changes of the open probability of mechanosensitive ion channels. Thus, acting on ion channels in the plasma membrane, mechanical stress can elicit a multitude of biochemical processes inside a cell, both transient and long-lasting. This may ultimately influence the function of tissues and organs in health and disease. Several stretch-induced signaling cascades have been described with multiple levels of crosstalk between the different pathways. Increased sensitivity of the cells...

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