Ox40
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Описание:
0x40 is a member of TNF receptor superfamily and is found on activated T cells (Watts and DeBenedette, 1999) but there is a difference in their expression patterns on T cell subsets. While in vitro studies showed the expression peaks at 48 hours following activation on both CD4 f and CD8+ T cells, the vivo experiments, on the other hand, demonstrate a selective expression on CD4+ T cells upon immunizing with adjuvant or under specific clinical conditions (Weinberg, 1998; Weinberg et al., 1998; Higgins et al, 1999). Ox40 is an activation-dependent molecule with a broad tissue distribution, and has been localized on activated T cells (Ваши et al, 1994), Ð’ cells (Calderhead et al., 1993), dendritic cells (Ohshima et al., 1997), and vascular endothelial cells (Imura et al., 1996). Data available indicate that both Ox40-Ox40L interactions and anti-Ox40-anti-CD3 combinations provide costimulation to T cells, resulting in elevated cytokine secretion (Weinberg et al, 1998). The authenticity of these findings was further substantiated by the findings that in Ox40-deficient mice the T helper responses were greatly diminished, while the Ð’ cell and CTL responses remain unaffected (Kopfet al., 1999). Also, studies with Ox40-Ig fusion protein demonstrate decreased T cell responses under the conditions tested (Weinberg et al., 1999). Ox40 has also been shown to play an important role in various disease conditions (Kaleeba etaL, 1998).Похожие книги
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