Pathological Pain
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Описание:
Recent decades have seen an explosion of research into the mechanisms of pain in both normal and pathological states. Neurobiological studies have revealed the detailed characteristics of nociceptive systems and endogenous analgesic systems. Such studies are, however, of only limited use in explaining the mechanisms implicated in pathological pain. Plastic changes in pain systems occur in chronic neuropathic pain, even resulting in structural changes within the CNS, and neuronal plasticity seems to be the key to a better understanding of pathological pain, perhaps reflecting the primitive and poorly differentiated nature of the pain system. In evolutionary terms, the pain system emerged at a very early stage of neuronal development. These early origins are reflected by its plasticity, its intimate relationship with instinctive and other fundamental bodily functions such as the autonomic nervous system, and the involvement of humoral signalling messengers. Recent progress in...Похожие книги
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