Pharmacophores and Pharmacophore Searches
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Описание:
In their search for new drugs, medicinal chemists are trying to pinpoint and optimize only the active part of a pharmaceutical substance, without interference from other parts of the molecule. The "pharmacophore" is a virtual representation of the active part of a drug that enables them to do just that. Once identified, pharmacophores can then be used for the screening of drug libraries and drug targets to find novel active substances that can be developed into drugs. This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field, progressing from general considerations to real life scenarios in drug discovery research. Starting with an introductory historical overview, the authors move on to discuss ligand–based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure–based approaches includes pharmacophores from ligand–protein...Похожие книги
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