Reversible Protein Acetylation
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Описание:
The reversible acetylation of lysine residues on histone proteins has emerged as a major factor in the regulation of transcription in eukaryotes. All core histone proteins are acetylated and unique functional chromosomal domains are characterized by specific patterns of acetylation within their histone proteins. Functional correlations have been established between the level of acetylation of individual genes and their transcriptional activity. These complex signals are currently being elucidated in the context of the‘histone code hypothesis’. This model posits that distinct acetylation patterns in histones, along with other post–translational modifications, serve as specific signals recognized by the nuclear transcriptional machinery. Histone acetylation is under the control of competing histone acetyltransferases (HATs) and histone deacetylases (HDACs). Both enzyme families contain many members: at least 18 distinct human HDACs have been identified. As well as regulating...Похожие книги
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