The Molecular Basis of Cellular Defence Mechanisms

The Molecular Basis of Cellular Defence Mechanisms
Автор
 
Год
 
Страниц
 
260
ISBN
 
9780470515280
Категория
 
Книги издательства Willey

Описание:

Much of the defence of the body against invading microorganisms has been delegated to two sets of haemopoietic cells?the T and B lymphoid cells, and the granulocytes and monocyte/macrophages. These have in common their ancestral origin from multipotential haemopoietic stem cells and the need to be produced continuously throughout life. This biology requires complex programmes of controlled cell division, differentiation, commitment and maturation, the molecular nature of which have been established in some detail. While there are unique features of the regulations of each of the four lineages, there is much in common in the manner in which corresponding processes are controlled by a group of interacting regulatory glycoproteins. Based largely on the use of clonal in vitro cultures, the regulators involved have been cloned and active recombinant regulators mass–produced. The membrane receptor complexes mediating the cellular actions of these regulators have been identified and at least...

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